Download PDF by Mark LeDoux (Editor): Animal Models of Movement Disorders

By Mark LeDoux (Editor)

ISBN-10: 0080470564

ISBN-13: 9780080470566

ISBN-10: 0120883821

ISBN-13: 9780120883820

Using animal versions is a key point of clinical examine in several fields of drugs. This ebook vigorously examines the real contributions and alertness of animal versions to the knowledge of human flow problems and may function a necessary source for uncomplicated neuroscientists engaged in flow problems learn. educational clinicians, translational researchers and easy scientists are introduced jointly to attach experimental findings made in several animal types to the medical good points, pathophysiology and therapy of human stream issues. an essential function of this booklet is an accompanying DVD with videos of human circulation issues and their corresponding animal types. The ebook is split into sections on Parkinson disorder, Huntington ailment, dystonia, tremor, paroxysmal stream problems, ataxia, myoclonus, stressed legs syndrome, drug-induced flow issues, a number of method atrophy, revolutionary supranuclear palsy/corticobasal degeneration and spasticity. This e-book serves as a vital source for either clinicians attracted to the technological know-how being generated with animal versions and simple scientists learning the pathogenesis of specific stream issues. * offers a unmarried entire source on animal versions of circulate problems that educational clinicians, translational researchers, and uncomplicated neuroscientists can consult with* contains contributions via specialist circulate ailment clinicians and top-level researchers within the box* incorporates a DVD containing over a hundred and seventy videos of human circulate problems and the corresponding animal versions

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Extra info for Animal Models of Movement Disorders

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The profound complexity of normal and abnormal neural networks cannot be reproduced in either the test tube or culture dish. Attempts to identify molecular, genetic, and neurophysiological defects in animal models of movement disorders have forced scientists to make more focused analyses of normal neural function and, as a result, significant advances have been made in motor systems physiology. For example, animal models of Parkinson disease and dystonia have contributed to our understanding of basal ganglia and cerebellar local area networks, respectively.

Elegans was the first multicellular eukaryote to have its complete genome sequenced. C. elegans normally lives in soil and eats bacteria such as E. coli. Worms contain rudimentary feeding, neural, and reproductive systems. C. elegans is quite easy to grow and can be frozen for long-term storage. Worms can even be maintained in 96-well plates for high-throughput analyses and genetic manipulations. For instance, worms parceled out among a large set of 96-well plates can be fed bacteria that express target-gene dsRNA for large-scale RNA interference (RNAi) experiments (Kamath and Ahringer 2003).

Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila. J Neurosci 24:3899–3906. K. Gupta, R. Thomas, V. R. L. Felten. 1986. Aged mice are more sensitive to 1-methyl-4-phenyl1,2,3,6-tetrahydropyridine treatment than young adults. Neurosci Lett 70:326–331. H. Meisler, and A. Richter. 2003. Motor disturbances in mice with deficiency of the sodium channel gene Scn8a show features of human dystonia. Exp Neurol 184:830–838. J. L. W. T. Bronson, V. J. Daly, et al.

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Animal Models of Movement Disorders by Mark LeDoux (Editor)


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