By Institute of Medicine, Board on Population Health and Public Health Practice, Committee on the Review of the Scientific Literature on Amyotrophic Lateral Sclerosis in Veterans
Amyotrophic lateral sclerosis (ALS) our Lou Gehrig's disorder is a deadly, often non-familial illness that has effects on the apprehensive process of people by way of inflicting the degeneration of nerve cells within the mind and spinal wire. The degeneration halts communique among the worried approach and voluntary muscle groups within the physique. This ends up in muscle paralysis and finally the muscle tissues that reduction in respiring are impact; inflicting respiratory to fail. The illness, which impacts 20,000-30,000 women and men within the usa at any given time, has no potent therapy; most folks with ALS die from respiration failure inside five years of the onset of symptoms.
Recent epidemiologic reviews file an organization among the advance of ALS and previous provider within the U.S. army. The stories evaluated both veterans of the 1991 Persian Gulf battle or veterans who served within the army within the interval 1910-1982. as a result of those findings, the dep. of Veterans Affairs (VA) requested the nationwide Academies to behavior an evaluate of the capability courting among army provider and the later improvement of ALS. The undertaking was once assigned to the Institute of medication (IOM), which appointed a committee and gave it the duty of comparing the medical literature on ALS in veterans.
The committee begun its paintings by means of settling on scientific and clinical literature on ALS. PubMed, a database created and controlled by means of the nationwide Library of medication. Amyotrophic Lateral Sclerosis in Veterans; evaluate of the clinical Literature provides the findings of this committee. The committee reviewed, evaluated, and summarized the medical literature on ALS in veterans, composed basically of peer-reviewed, released literature. This file comprises the options of the committee.
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Extra info for Amyotrophic Lateral Sclerosis in Veterans: Review of the Scientific Literature
Prospective study of military service and mortality from ALS. Neurology 64(1): 32-37. A EXAMPLES OF RISK FACTORS POSSIBLY RELEVANT TO MILITARY SERVICE The committee summarizes below several studies of putative risk factors for amyotrophic lateral sclerosis (ALS) relevant to military personnel. This section is not a comprehensive review or critique; rather it highlights selected studies thought to be of relevance. PHYSICAL ACTIVITY A number of studies have examined the association between workplace and leisure-time physical activity and ALS.
Risk of amyotrophic lateral sclerosis and history of physical activity: a population-based case-control study. Archives of Neurology 55(2):201-206. , Nelson LM, Koepsell TD, Checkoway H, Morgan MS, van Belle G. 1997. Occupational exposures and amyotrophic lateral sclerosis. A populationbased case-control study. American Journal of Epidemiology 145(12):1076-1088. Murch SJ, Cox PA, Banack SA. 2004a. A mechanism for slow release of biomagnified cyanobacterial neurotoxins and neurodegenerative disease in Guam.
A recent study of 7,325 male Italian professional football (soccer) players over the period 1970-2003 revealed an increased incidence of ALS relative to what would have been expected given ALS incidence in the general population in Italy (Chio et al. 2005). 1). 4). CIGARETTE-SMOKING AND ALCOHOL CONSUMPTION A case-control study of 110 newly diagnosed ALS patients from two centers in New England and 210 population-based controls examined demographic characteristics, family history of ALS, and histories of smoking and alcohol consumption (Kamel et al.
Amyotrophic Lateral Sclerosis in Veterans: Review of the Scientific Literature by Institute of Medicine, Board on Population Health and Public Health Practice, Committee on the Review of the Scientific Literature on Amyotrophic Lateral Sclerosis in Veterans