By John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr. Michael I. Lethem (eds.)
Conceptually unsavoury, airway mucus is key to homeostasis within the breathing tract. against this, whilst irregular, mucus contributes considerably to the pathophysiology of a few critical bronchial illnesses, together with bronchial asthma, power bronchitis and cystic fibrosis. This quantity presents broad ranging and in-depth insurance of the medical and scientific facets of airway mucus. It commences with introductory chapters which handle the biochemical and molecular organic foundation of airway mucus and keeps with entire insurance of a number of the physiological and rheological points of respiration secretions. The medical points of the subject are then thought of, with chapters discussing the involvement of mucus secretions in bacterial an infection and in hypersecretory illnesses of the airway. the quantity concludes with a dialogue of the healing features of the subject, either by way of the prospective ways to the therapy of mucus hypersecretion and the interplay of those medications with airway mucus. Written via top specialists within the box, every one contribution presents a finished overview of its specific topic. Reflecting the newest advances during this vital region of breathing examine, this quantity should be of significant curiosity to scientists and clinicians operating within the box of airway secretions and similar areas.
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Extra info for Airway Mucus: Basic Mechanisms and Clinical Perspectives
E) Transmembrane domain. Classically, mucins have been considered to be secreted macromolecules. The three completed MUC ORFs encode leader sequences, which direct nascent protein chains into the endoplasmic reticulum for processing as membrane or secreted glycoproteins. Uniquely, MUCl encodes a hydrophobic transmembrane domain within its carboxyl terminus domain and presents as a type-l membrane glycoprotein. If proteolysis occurs in the extracellular milieu, MUCl glycopeptide is released into the secretions .
Pemberton L, Taylor-Papidimitriou J, Gendler S (1992) Antibodies to the cytoplasmic domain of the MUCI mucin show conservation throughout mammals. Biochem Biophys Res Commun 185: 167-175. 37. Jany BH, Gallup MW, Yan PS, Gum JR, Kim YS, Basbaum CB (1991) Human bronchus and intestine express the same mucin gene. J Clin Invest 87: 77-82. 38. Dohrman A, Tsuda T, Escudier E, Cardone M, Jany B, Gum J, Basbaum C (1994) Distribution oflysozyme and mucin (MUC2 and MUC3) mRNA in human bronchus. Exp Lung Res 20: 367-380.
To this end, we have employed density-gradient centrifugation, ionexchange chromatography and agarose gel electrophoresis to identify three mucin populations which together comprise the bulk of the gel-forming species [46, 47, 62], and an example is shown in Figure 3. These three components are all high-Mr polymeric species that are fragmented into their constituent subunits by reducing agents, and as such all conform to the macromolecular design described earlier. One of the mucins was identified as the product of the MUC5AC gene, whilst the genetic identity of the other two, which for the purpose of this article we will term MUCX and MUCY, has yet to be elucidated.
Airway Mucus: Basic Mechanisms and Clinical Perspectives by John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr. Michael I. Lethem (eds.)